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Renal effects of empagliflozin in patients hospitalized for acute heart failure: from the EMPULSE trial

Eur J Heart Fail. 2022; online ahead of print DOI: 10.1002/ejhf.2681

The present study showed that the beneficial clinical effects of empagliflozin were consistent regardless of baseline estimated glomerular filtration rate (eGFR). Empagliflozin caused an early modest decline in renal function, but after 90 days, there was no difference between the empagliflozin and placebo groups. Overall, renal adverse events were similar between the groups.


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